Are there points of no return or lockout for side content in Red Dead Redemption 2?

The game can feel a bit like a slog with how realistic and slow it is for animations and traveling. I was wondering if I power through the main story will I remove my ability to complete certain side content because it is time sensitive to where you are in the main story? Thanks.
Best Answer
There is at least one achievement/trophy you can miss if you simply power through the story: you need to fulfill 5 camp companion requests and will not be able to do this if you progress all the way to the epilogue. You can also miss opportunities asking since some companion requests are restricted to specific camps.
There are some other side missions that are chapter specific, as time does pass at the rate of weeks, months, and even years through the story.
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Is there a point of no return in RDR2?
Is There a Red Dead Redemption 2 Point of No Return? The Chapter 6 mission \u201cOur Best Selves\u201d which you get from Dutch is the mission that kicks off the Red Dead Redemption 2 point of no return. From there, you're locked in until the end of the chapter. The mission that precedes this, for reference, is \u201cMy Last Boy.\u201dCan you go back and do side missions RDR2?
After beating RDR2's single-player campaign, the so-called "post game" can extend well beyond the conclusion of Epilogue II, with Red Dead 2's endgame giving you the option to go back and complete (almost) all of the Quests and Side Quests, as well as Collectible sets that you may have skipped or left incomplete before ...Are side missions important in RDR2?
These side quests don't have any effect on your progress through the story, but if you're aiming for that elusive Red Dead Redemption 2 100% completion accolade then you'll have to track them down at some time anyway, so you might as well catch up with them on your journey.Can you skip side missions in RDR2?
Unlike its predecessor, Red Dead Redemption 2 contains missions, items and other content that can be permanently missed in a save file unless obtained, studied or otherwise interacted with during a certain time-frame.What Happens If You DON'T Go Visit Thomas Downes In Red Dead Redemption 2? (RDR2 SECRET Outcome)
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