Can you still combo break an opponent's move with no life bar?

I'm watching several videos on YouTube regarding the latest edition of Killer Instinct and noticed that many Ultra combos are started when their opponent's life bar is near empty. I know that you can use Combo Breakers to interrupt a Combo midway (or a player can use a Shadow Cancel to interrupt a Combo Breaker).
Such as in this video (done without combo breakers, also careful this is a 30 minute video):
My question is: When a player's lifebar depletes, can they still perform Combo Breaker's or do the controls of the (soon-to-be) defeated player not respond when a player has no lifebar?
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How do you break a combination?
When your opponent hits you with any attack in the combo sequence, simply press the punch and kick buttons that match the strength of the offense's attack, and you will perform a combo breaker (you can also perform some shortcuts.How do you combo break in Killer Instinct SNES?
The rebooted Killer Instinct again reworks Combo Breakers. They are now executed by inputting a Punch and Kick of the same button strength, corresponding with the strength of the attacker's hit (ex. use (LP+LK) to break a Light auto-double).WWE 2K22 - How To Reverse Everything! (COMBO BREAKER)
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Images: Ketut Subiyanto, Ylanite Koppens, Ylanite Koppens, Engin Akyurt