Do I have to pick an item to unlock it?

I need to unlock a couple items from Angel Room and Secrets Room so I would like to know if it is enough to see it as I use the D6 or I do have to pick it to count.

the-binding-of-isaac-rebirth

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How do you unlock Godhead?

You just need to complete the Lost's post-it on Hard to unlock Godhead.

What do I unlock first in Isaac repentance?

First off, unlock Bethany and use her to defeat Mother (the one that used to be The Witness). This is really more of a "two birds with one stone" thing because Revelation is insane and your next unlock is... The Red Key!

How do I unlock the starting items in binding of Isaac?

Unlock Method

The Lost starts with flight.

The Lost starts with flight, spectral tears, D4 (if unlocked) and Holy Mantle (after donating 879 coins to the. ...

The Lost starts with flight, spectral tears, Eternal D6, and the effect of Holy Mantle (after donating 879 coins to the Greed Donation Machine).

Essential Unlockables - The Complete Guide (The Binding of Isaac: Afterbirth+)

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Images: Andrea Piacquadio, Eren Li, Sam Lion, cottonbro