Do I have to run SKSE to launch Skyrim every time?

I downloaded SKSE (Skyrim Script Extender) and started Skyrim the normal way but I got popups that SKSE was not working properly. I then ran SKSE and it worked properly. But the question is do I really have to run this every time I play?
Best Answer
SKSE is required for some 3rd party mods to function. It will usually indicate on the mod's download page whether SKSE is required (at least on sites like Nexus.)
If you're happy to play Skyrim without your 3rd party mods, or with those mods potentially not working properly, you can run the standard executable and the game will work. SKSE will not be affected if you do this.
However, if you want to play with your 3rd party mods, you will need to continue running SKSE as your method of launching Skyrim.
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How do I launch Skyrim with SKSE?
Launch the game by running skse_loader.exe. If you use a desktop shortcut to launch Skyrim normally, just update the shortcut to point to skse_loader.exe instead of TESV.exe or SkyrimLauncher.exe and then exit the game. If you launch the game from a shortcut in the start menu, update that shortcut.Can you mod Skyrim without SKSE?
SKSE is a necessary plugin for most of the Skyrim mods. So we recommend you to download it first before you install mods.How do I know if SKSE is active?
If you are using Vortex as your mod manager, then yes, you should be launching with Vortex in order to insure that SKSE and its dependent stuff and your mods get loaded properly. If you're just playing Special Edition (or Legendary Edition) without mods or SKSE, then it doesn't matter.Launch Skyrim Special Edition | Launch Through SKSE | Four Ways to Launch SSE
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