How can I find the NPCs I need to eliminate in Elite: Dangerous?

There are a lot of missions in the Bulletin Board which require you to eliminate someone. I did not manage to find a single one of them and I always ended up failing the mission even after an hour spent searching. What am I doing wrong? How do I find my targets fast? What are the leads?
In the last mission I failed the NPC was speaking in local chat while I was searching for him but I did not find him anywhere. I think that these missions are extremely hard compared to the smuggling missions I can get for the same rewards.
Best Answer
You want to look almost exclusively for Unknown Signal Sources in their last known location/system. Its good to have an interdictor in case they jump away, too.
I have also found a target in Supercruise, after I had chased him away from an Unknown Signal source. I have never located one, personally, anywhere other than an Unknown Signal Source or a location they ran to from a source.
The wiki hints at USS's containing "Unique NPCs", I think they're referring mainly to targets of bounties and/or missions.
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