How to use hotkeys when focused program disables them?

I'm a power user, a game dev student, and and a twitch streamer, so multitasking is important to me. That having been said, programs like OBS and Voice Warrior require hotkeys to be used effectively. However, when certain programs (games mainly) are "focused" in Windows it's impossible to use them outside of that program save a few exceptions like peekthrough and Borderless Gaming. I know it's possible to disable focus altogether via regedit, but from my understanding this dramatically increases cpu usage, which I don't have much to spare. I've also heard autohotkey can fix this, but I haven't found a proper script to do so, nor am I proficient in the software's language to write a script to do so, does anyone have an editable script on hand or some other method to neutralize this hotkey disabling?