In the Diablo games, how can a human defeat demons?

In the Diablo games (I, II and III), the player controls a warrior of some kind (sorcerer, barbarian, etc.), which is basically human (except in III, where he is a Nephalem, but I am not exactly sure how that makes the differnce). Eventually, the player gets to defeat great demons, including Mephisto, Baal, Malthael, etc.

In the Diablo world, how do they explain this? How can a human ever be powerful enough to defeat a demon, especially the Prime Evils?

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Are humans Nephalem?

Nephalems are the children of the angel and demon who created the sanctuary. Basically they are the humans in the Sanctuary.

What is demon Diablo?

Demons, otherwise known as Hellspawn, Demonkind, and the Minions of Darkness are evil entities native to the Burning Hells, and are the primary enemies of the Diablo series. They come in a variety of shapes and sizes and can wield a wide range of magical powers depending on their type.

Who is Nephalem Diablo 3?

Nephalem (Diablo III spelling), or Nephilim (as they are called in the Bible,) are the offspring of the "sons of God" and the "daughters of men" as quoted in Genesis. The term "Nephilim" occurs twice in the Bible, both in the Torah.

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