Is there a certain strategy for defeating Saddler?

As you know, he is the hardest boss to kill in the game. I don't really have an employed winning strategy. Any suggestions?
Best Answer
It's been a while since I played Resident Evil 4, so I consulted a few game guide's for the boss sequence.
When Saddler attacks you can press dodge to avoid the attack, or prompt a quick time event to avoid the attack.
Hit Saddler with explosives. This seems to work the best. Grenade launchers or the RPG will work best. There ar explosive barrels around you can lure Saddler near to set off.
Shoot Saddler's leg eyes. These are the weak spots for shooting Saddler with guns.
When Saddler is stunned you can run up to him for a quick time event that deals extra damage.
When Saddler's health is low Ada will throw you an RPG. Make the shot count, but hit Saddler once with it and it will be all over.
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How do you kill Saddler in Resident Evil 4 professional?
The player can kick Verdugo via action command when it is initially frozen. After a varied amount of time, the Verdugo will break out of its nitrogen casing and return to normal again. While frozen, it receives tripled damage and a direct hit from a Rocket Launcher will be an instant kill.How do you kill Verdugo?
Use either a shotgun or a TMP to hit it. Once Salazar reveals himself, use a magnum to unleash serious damage against him. With the power of a Broken Butterfly or Killer 7, Leon should only have to do this two times or so to beat Salazar.How do you beat the boss in re4?
After you beat the game, this weapon is offered for sale by all the merchants you encounter for 1 million pesetas. With it, you can kill almost any enemy in the game, including Leon and Ashley.RE4 | Killing Saddler! (The Easy Way)
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