Skyrim Thieves Guild Quests

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So I completed the quest line that destroys Heimskr's house in Whiterun so I can't complete one of the jobs for the thieves guild. Will this hinder my game?
Edit: you need these quests to upgrade the thieves guild, so I am assuming I will never be able to fully upgrade.
Best Answer
Heimskyr's house is not part of any main Thieves Guild quest- only the radiant quests. These quests can be cancelled and replaced by talking to Vex or Delvin.
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How many quests does it take to restore the Thieves Guild?
You have to do a total of five jobs, whether from Delvin or Vex, in each hold and finish those special quests in order to bring it back into business.What is the fastest way to restore the Thieves Guild?
In order to restore the Thieves Guild to its former glory and assume the title of Guild Master, you must perform small jobs in four holds of Skyrim: Haafingar, the Reach, Whiterun, and Eastmarch. To get an improvement job, talk to Delvin Mallory or Vex; you can have one quest active from each.Can you run out of Thieves Guild quests?
The thieves guild quests are what's called "radiant" quests, and there's basically no limit to them and they never run out. You can quit as many as you want to with no bad results.Is there a quest to take down the Thieves Guild in Skyrim?
Sadly, there is no quest to destroy the Thieves Guild in Skyrim.Skyrim - Thieves Guild Questline - Full Playthrough (HD PS3 Gameplay)
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