What's the difference between a rune and an infusion?

What's the difference between a rune and an infusion? - A Girl Drawing Circles on Face

I don't really understand what the difference is between a rune and an infusion. The wiki for the game says:

Inscriptions come in two flavors: runes and infusions. Runes are magical glyphs drawn on the body like temporary tattoos. Infusions are natural substances smeared/attached to the body, like nicotine patches.

That doesn't really clear it up for me. I'm assuming there is a mechanical difference and not just a thematic difference?

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