Where do Harbingers spawn?

I'm trying to get Meat Boy and Bandage Girl achievements and this is driving me nuts.

I know I have to defeat all 4 Harbingers (a.k.a The Horsemen) in one run, but I can't find them. It's not easy to find the Book of Revelations, and each time I get it I find a Double Trouble boss room that ruin my run, or one of the other Horsemen that drop a Pony item (Headless and Conquest).

I've tried the Monster Manual strategy, too, but in 7 hours and 30+ Manual activations I haven't got a damn Cube of Meat at all.

So I'm pretty discouraged, and I've restarted my runs infinite times because of wrong bosses. This is a slow process.

To save a bit of time, I've heard that Harbingers only spawn as the first boss of each set of floors (Basement/Cellar, Caves/Catacombs, Depths/Necropolis and Womb/Utero). So my question is:

Is this true? Or should I try to fight Basement/Cellar II boss before restarting?

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What is a harbinger path of exile?

A Harbinger. Harbingers are a type of immortal monsters. Harbingers summon enemies to fight the player while empowering them in different ways, and they can only be harmed by killing their minions. Harbingers can drop currency shards, for both ones seen in Wraeclast as well as their own currency.

How do I get the harbinger Orb?

Harbinger's Orb is created exclusively from combining shards. In addition, Harbinger's Orbs can also be found in an Immortal Syndicate Fortification safehouse if Cameria is placed there. There are other mechanics that drop drop-restricted item like Harbinger's Orb, such as Harbinger chest of Heist and Grand Heist.

What are the four horsemen binding of Isaac?

In the Bible, Conquest is actually the first Horseman to appear, while Pestilence is a Horseman existing only in popular culture, coming from a different translation of the Greek word 'Thanatos', often meaning Death instead (the canon four Horsemen, thus, are Conquest, War, Famine and Death).

What is a harbinger unique?

Harbinger unique items are items introduced in Harbinger and Harvest league, which associated with Harbinger, a type of unique monsters. Harbinger items, according to in-game description, can also obtain from relevant game mechanics from other league, such as Foreboding Incubator.

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