Can Special Combo Takedown be used on any enemy?

In Batman: Arkham City you can execute a variety of special combat moves once your combo meter is up (e.g. that multiple batarang move, the super bat stun thing, etc.). One of these moves is the Special Combo takedown which is supposed to be "an unblockable takedown that will instantly K.O. an enemy."
Now I've used this move many a time on normal thug enemies, but I am wondering if it also works on the bigger guys, such as lieutenants and titans?
It's pretty hard to attempt this myself as there are usually many other normal thug enemies that my character will default to using the attack on first, and I don't want to lose my combo.
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How do you do special combo takedowns in Arkham Knight?
The default command for this move is \u25b3+\u25cb on PlayStation, Y+B on XBox, T on PC prior to Batman: Arkham Knight, and Alt+2 on PC in Knight. This move is only available for Batman and Azrael.How do you do a Special Combo Multi Ground Takedown?
Hold the upper side of a shield with one hand, punch the thug holding it through the glass to separate him from it, then kick on it to break it.How do you break enemy weapons in Arkham Knight?
The attack allows Batman (and certain other characters, see below) to take down up to 6 enemies in rapid succession. It's activated by pressing Square/X/PC when near a group of enemies, and can also be activated by performing a knockout smash during any takedown.How to MASTER Combat in the Batman Arkham Games EASILY! (The Ultimate Guide)
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