Do attack speed debuffs affect champions with auto-attack resets and auto-attack cancel spells?

This question is highly focused on auto-attack based attack damage caster champions with a spell that can reset their auto-attack or cancel their attack animation in such a way as to allow them to deal their damage faster. I am interested in learning if attack speed debuff abilities/items help in anyway to limit this burst in terms of execution not damage.

So I will explain my question further with an example.

You are in a Riven vs Nasus lane you're Nasus. Nasus W(wither) is an attack speed/movement slow. Riven can Q(broken wings), AA(auto-attack), using that she can deal a large amount of damage in a short period of time by breaking her attack animation with her Q. Now if you were to use your wither you would be able to easily escape however if you can not(she flash W(ki burst) on you) does your W affect her or will her attack timer reset on Q still allow her to AA thrice while she combos with her Q.

To conclude I simply want to know if attack speed debuffs helps in reducing a champions burst potential by limiting the amount of time it takes for them to deal their damage while you attempt to escape or beat them.