What are the consequences of travelling to the Isle of Mists?

I'm currently reluctant to continue the main story of the game because every time I get close to the Isle of Mists I receive multiple warning messages telling me to save my game and that going further will have heavy impact on the game and making progress.

Can someone explain what I won't be able to accomplish after travelling to the Isle of Mists? Will only some quests be affected by this? Will NPCs be gone? (Bonus points if you can manage to tell me without using spoilers.)

The message I see sounds very drastically so I'm afraid I won't be able to finish a lot of quests that I have (not yet) accepted and not finished yet.

the-witcher-3

Pictures about "What are the consequences of travelling to the Isle of Mists?"

What are the consequences of travelling to the Isle of Mists? - Person Wearing Black Jacket Standing on Green Grass Field Near Lake

What are the consequences of travelling to the Isle of Mists? - City Skyline during Night Time

What are the consequences of travelling to the Isle of Mists? - Drone view of rocky isle washed with blue water of turquoise ocean under cloudy sky

What quests fail when you go to the Isle of Mists?

The following quests fail or become unavailable if they are not completed before entering the Isle of Mists:

A Dangerous Game.
A Deadly Plot.
A Favor for a Friend.
A Matter of Life and Death.
A Towerful of Mice.
An Eye for an Eye.
Berengar's Blade.
Brothers In Arms: Nilfgaard.

Can you go straight to the Isle of Mists?

Getting To The IsleThe Isle of Mists is only accessible from the seas in Skellige. So, you need to grab a boat from the Kaer Trolde harbor and head southeast. However, if you're not in the mood for traversing the sea, you can always fast travel to a closer harbor (while in the boat).

What to do before going to the island of the mist?

At the absolute minimum, it is highly recommended that you complete the following before you start Isle of Mists:

Brothers in Arms: Velen.
Brothers in Arms: Novigrad.
Brothers in Arms: Skellige.
Brothers in Arms: Nilfgaard - just visit the emperor in Vizima, no walkthrough needed.
Recruit Letho, if alive.

Is there anything you can miss on the Isle of Mists?

There isn't any unique loot or place of Power on the Isle of Mists. You can nonetheless find many chests with random loot. The island is small and the chests are not too distant to each other.

The Witcher 3: Wild Hunt | The Isle Of Mists - Travel To The Isle Of Mists

Sources: Stack Exchange - This article follows the attribution requirements of Stack Exchange and is licensed under CC BY-SA 3.0.

Images: Paul Daley, Gabriela Palai, Hugo Magalhaes, Erik Mclean